Inflammation. Disc Degeneration. There is a connection.
Inflammation acts as the body’s response system to harmful
stimuli (injury, pathogens, metabolic stress – a disc herniation pushing
on a nerve!) as it attempts to restore itself to normal
before the harm was done. Paramus Medical & Sports Rehabilitation Center is never
shocked at how the body takes care of itself!
Paramus Medical & Sports Rehabilitation Center sees its Paramus chiropractic care as a partner of
the body’s system in healing particularly
when there is spine pain. Chiropractic care uses
many tools like spinal manipulation, exercise, and nutrition to take care of
the body. Melatonin is one nutritional tool that is proving value
by interrupting the inflammatory process
related disc herniation that brings about pain relief: back, neck, spine-related.
DISC DEGENERATION AND INFLAMMATION AND 'AUTOPHAGY'
Inflammatory markers interleukin-1β (IL-1β), interleukin-6
(IL-6) and tumor necrosis factor-α (TNF-α) are linked to intervertebral disc degeneration. (1) IL-1 β actually promotes
itself, its own expression, by upregulating NLRP3 inflammasome activation. (2)
The body controls itself down to the cellular level
via autophagy, the natural process during which the body’s
cells clear out damaged (ie, by inflammation) or unneeded parts. In
a new study, melatonin enhanced autophagy
and reduced the degradation of the disc’s
extracellular matrix (technically marked by a decline
in marker LC3B, autophagasomes and autolysosomes and inhibition of the NF-kB
signaling pathway). The final conclusion was that melatonin prevents
intervertebral disc degeneration by promoting autophagy. (3)
Wow. Paramus Medical & Sports Rehabilitation Center is encouraged by this research to see just
how well melatonin can work for Paramus back pain linked
to disc degeneration.
MELATONIN AND ITS HEALING WAYS FOR THE DISC
Disc degeneration is a very common condition
seen at Paramus Medical & Sports Rehabilitation Center that positive news of
melatonin’s benefits are quite exciting. A recent
study stated that melatonin could modify
the extracellular matrix of the disc remodeling process initiated
by IL-1 β. Further, melatonin reduced the
inflammatory cell collection and reduced the release of linked
inflammatory markers IL-1β, IL-6, and TNF-α. With this new discovery
that melatonin disrupted the IL-1B feedback loop, researchers
proposed that melatonin may support
the restoration process of intervertebral discs after damage was
already present. (1) Paramus Medical & Sports Rehabilitation Center will keep
following the new research regarding the role inflammation has
in Paramus disc degeneration and melatonin’s role in tackling
INFLAMMATION AND MELATONIN
The significance of melatonin in assisting
to slow or stop painful conditions due to inflammation is growing.
The description of melatonin as a multitasking molecule affecting
mood, immunity, and energy among other mechanisms is quite suitable.
It’s also anti-oxidant, anti-aging, and anti-inflammatory, specifically
by hindering the activation of inflammasomes (4) Melatonin’s
formal chemical name is as about as long as its list of tasks: N-acetyl-5-methoxytryptamine.
The pineal gland secretes melatonin naturally. Melatonin impacts
the body’s aging, anti-inflammatory, anti-apoptosis (cell death), and autophagy
(cell-cleanout) activities. (1) Melatonin’s specific influence on
inflammation and disc degeneration is most interesting
to Paramus Medical & Sports Rehabilitation Center and our Paramus back pain patients.
CONTACT Paramus Medical & Sports Rehabilitation Center
Listen to this PODCAST
with Dr. Hrefna Sylvia based in Iceland where back pain isn’t much different
from any other country on The Back Doctors Podcast with Dr.
Michael Johnson as she illustrates how The Cox® Technic
System of Spinal Pain Management addresses disc
degeneration for relief of chronic low back pain in her patient.
Schedule your Paramus chiropractic appointment with
Paramus Medical & Sports Rehabilitation Center today. We can talk about how inflammation affects your
back pain and how melatonin may help with the related disc